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About Dr. Bredesen 2017-01-25T11:47:44-08:00

Dr. Dale Bredesen

Dr. Bredesen is internationally recognized as an expert in the mechanisms of Color version of Dale Bredesen board portraitneurodegenerative diseases such as Alzheimer’s disease. He graduated from Caltech, then earned his MD from Duke University Medical Center in Durham, NC. He served as Chief Resident in Neurology at the University of California, San Francisco (UCSF) before joining Nobel laureate Stanley Prusiner’s laboratory at UCSF as an NIH Postdoctoral Fellow. He held faculty positions at UCSF, UCLA and the University of California, San Diego. Dr. Bredesen directed the Program on Aging at the Burnham Institute before coming to the Buck Institute in 1998 as its founding President and CEO.

The uniform failure of recent drug trials in Alzheimer’s disease has highlighted the critical need for a more accurate understanding of the fundamental nature of Alzheimer’s disease. Dr. Bredesen’s research has led to new insight that explains the erosion of memory seen in Alzheimer’s disease, and has opened the door to a new therapeutic approach. He has found evidence that Alzheimer’s disease stems from an imbalance in nerve cell signaling: in the normal brain, specific signals foster nerve connections and memory making, while balancing signals support memory breaking, allowing irrelevant information to be forgotten. But in Alzheimer’s disease, the balance of these opposing signals is disturbed, nerve connections are suppressed, and memories are lost. This model is contrary to popular dogma that Alzheimer’s is a disease of toxicity, caused by the accumulation of sticky plaques in the brain. Bredesen believes the amyloid beta peptide, the source of the plaques, has a normal function in the brain — promoting signals that allow some of the nerve connections to lapse. Thus the increase in the peptide that occurs in Alzheimer’s disease shifts the memory-making vs. memory-breaking balance in favor of memory loss. This work has led to the identification of several new therapeutic candidates that are currently in pre-clinical trials.

Dr. Bredesen’s novel insights into the fundamental nature of Alzheimer’s disease recently attracted an investment of $3.5 million toward a $10 million goal for initial clinical trials of these new therapeutics. This generous support came from the private venture capitalist Douglas Rosenberg, who is helping to fund the Alzheimer’s Drug Discovery Network, centered at the Buck Institute. The unit is screening drug candidates to find those that can preserve a healthy balance in the signaling pathways that support memory. Dr. Bredesen’s work on nerve cell signaling is also the focus of a collaboration between the Buck Institute and BioMarin Pharmaceuticals, Inc., which is seeking treatments for a rare form of Alzheimer’s disease, early onset Familial Alzheimer’s Disease (eFAD), which may develop in people as young as 30 years of age.

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Augustus Rose Professor and Director

Easton Center for Alzheimer’s Disease Research

David Geffen School of Medicine at UCLA, Los Angeles, CA

Founding President and CEO, Buck Institute for Research on Aging, Novato, CA

Dr. Bredesen’s Detailed C.V.

PUBLICATIONS–2016

Dale E. Bredesen, Edwin C. Amos… Jamila Ahdidan Reversal of cognitive decline in Alzheimer’s disease” Impact Aging

Dale E. Bredesen, Inhalational Alzheimer’s disease: An unrecognized—and treatable—epidemicImpact Aging

Theendakara V, Peters-Libeu CA, Spilman P, Poksay KS, Bredesen DE, Rao RV. “Direct Transcriptional Effects of Apolipoprotein E J Neurosci. 2016 Jan 20 pubmed

Qiang Zhang, Guiping Du… Dale E Bredesen Alzheimer’s Model Develops Early ADHD Syndrome. J Neurol Neurophysiol 6:6 1-6  pubmed


PUBLICATIONS–2015

H Michael Ellerby, Dale E Bredesen… Varghese John Correction to Hunter-Killer Peptide (HKP) for Targeted Therapy. J. Med. Chem. 58:4 2045 pubmed

Milan Fiala, Ramesh C Halder… Dale E Bredesen ω-3 Supplementation increases amyloid-β phagocytosis and resolvin D1 in patients with minor cognitive impairment.FASEB J. 29:7 2681-9 pubmed

Alexei Kurakin, Dale E Bredesen… Dale E Bredesen Dynamic self-guiding analysis of Alzheimer’s disease. Oncotarget 6:16 14092-14122 pubmed

Dale E Bredesen, … Dale E Bredesen Metabolic profiling distinguishes three subtypes of Alzheimer’s disease. Aging (Albany NY) 7:8 595-600 pubmed

Clare Peters-Libeu, Jesus Campagna… Varghese John sAβPPα is a Potent Endogenous Inhibitor of BACE1. J. Alzheimers Dis. 47:3 545-55 pubmed



 MORE PUBLICATIONS–BEFORE 2015  >